Vancouver, Canada. July 15, 2021 – NervGen Pharma Corp. (TSX-V: NGEN) (OTCQX: NGENF) (“NervGen” or the “Company”), a clinical stage biotech company dedicated to creating innovative solutions for the treatment of nervous system damage, today announced the formation of its Multiple Sclerosis (MS) Clinical Advisory Board comprised of six world-class scientific and clinical researchers in the field of multiple sclerosis: Drs. Jack Antel, Peter Calabresi, Jeremy Chataway, Jeffrey Cohen, Robert Naismith and Anneke van der Walt. This Clinical Advisory Board will work closely with NervGen as the Company prepares for its upcoming Phase 2 clinical trial in MS with its lead compound, NVG-291.

NervGen’s announcement of its MS Clinical Advisory Board comes in advance of The World Federation of Neurology’s annual World Brain Day on July 22. The focus and theme of this year’s day long global event is to “Stop Multiple Sclerosis”. With over 2.8 million people affected worldwide by MS and a new life-altering diagnosis of MS occurring every five minutes, there remains a great unmet need for new therapeutic approaches to either halt the disease’s progression or to repair the damage already caused by its advance. With the world’s attention being drawn to MS next week, NervGen believes its groundbreaking approach, together with the potential therapeutic benefits it may achieve, offers new hope for MS patients and their families.

“I am excited about the uniquely differentiated approach that NVG-291 may provide as a neurorestorative therapy for MS patients,” stated Dr. Dan Mikol, NervGen’s Chief Medical Officer. “Whilst currently approved disease-modifying therapies for MS target the immune system with the aim of reducing inflammatory activity and relapses and slowing disease progression, NVG-291 offers a distinctly different and powerful approach aimed at sustained improvement of function. With its multimodal mechanism of action resulting in enhanced remyelination, axonal regeneration and plasticity, NVG-291 has the potential to repair damage caused by MS and would represent a completely new treatment paradigm for those suffering from MS.”

NervGen’s President & CEO, Paul Brennan, added, “With this year’s World Brain Day focusing on both the industry and public’s attention on the life altering and often devastating effects of MS, we are both excited and proud to be moving a potentially game-changing therapy into a MS clinical trial next year. We are honored to have assembled such an esteemed and dedicated group of experts willing to share their combined decades of experience to advise us on our upcoming Phase 2 study and overall MS clinical development program. Our ability to attract these top tier scientific and clinical experts to both our multiple sclerosis and Alzheimer’s Advisory Boards reflects the unique and significant potential of our therapeutic platform to treating damage to the central nervous system.” Brennan concluded, “NVG-291 is the culmination of over twenty years of research and represents the emergence of an exciting new drug class to the pharmaceutical industry and to the central nervous system space specifically.”

The MS Clinical Advisory Board established by NervGen includes the following members:


About NVG-291
NVG-291, modulates protein tyrosine phosphatase (PTPσ), the key receptor for chondroitin sulfate proteoglycans (CSPGs). PTPσ and CSPGs have been shown to impede repair following injury to the nervous system, whether a result of trauma, such as in the case of spinal cord injury or traumatic brain injury, or disease-specific mechanisms, such as multiple sclerosis or Alzheimer’s disease. NVG-291 promotes neural repair mechanisms such as axonal regeneration; remyelination; plasticity; autophagy (a cellular self-cleaning mechanism that removes unnecessary or dysfunctional components); and a non-inflammatory phenotype in microglia cells, the innate immune cells of the central nervous system.

A Phase 1 trial of NVG-291 in heathy subjects is ongoing and, upon completion of the multiple ascending dose portion of the trial, NervGen intends to initiate a Phase 1b trial in Alzheimer’s disease patients. Concurrently, the Company also plans to initiate Phase 2 trials in spinal cord injury and multiple sclerosis with each of these trials planned to start in 2022.

About NervGen
NervGen is restoring life’s potential by creating innovative solutions for the treatment of nervous system injury due to trauma or disease as a result of underlying inflammation and/or neurodegeneration. The Company is initially developing drugs for the treatment of multiple sclerosis, spinal cord injury and

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Cautionary Note Regarding Forward-Looking Statements
This news release may contain “forward-looking information” and “forward-looking statements” within the meaning of applicable Canadian and United States securities legislation. Such forward-looking statements and information herein include, but are not limited to, the Company’s current and future plans, expectations and intentions, results, levels of activity, performance, goals or achievements, or any other future events or developments constitute forward-looking statements, and the words “may”, “will”, “would”, “should”, “could”, “expect”, “plan”, “intend”, “trend”, “indication”, “anticipate”, “believe”, “estimate”, “predict”, “likely” or “potential”, or the negative or other variations of these words or other comparable words or phrases, are intended to identify forward-looking statements. Forward-looking statements include, without limitation, statements relating to: our belief that NVG-291 offers new hope to MS patients; the preclinical and clinical development of NVG-291; our belief that the multi-modal mechanism of action of NVG-291 has the potential to repair damage caused by MS and would represent a completely new treatment paradigm for those suffering from MS; the timing, objectives and study design of the ongoing and proposed clinical studies for NVG-291; the need for new drug targets/mechanisms of action to treat MS; our belief that NVG-291 represents the emergence of an exciting new drug class to the pharmaceutical industry; and the creation of innovative solutions for the treatment of nerve damage and neurodegenerative diseases.

Forward-looking statements are based on estimates and assumptions made by the Company in light of management’s experience and perception of historical trends, current conditions and expected future developments, as well as other factors that we believe are appropriate and reasonable in the circumstances. In making forward-looking statements, the Company has relied on various assumptions, including, but not limited to: the Company’s ability to manage the effects of the COVID-19 pandemic; the accuracy of the Company’s financial projections; the Company obtaining positive results in its clinical and other trials; the Company obtaining necessary regulatory approvals; and general business, market and economic conditions.

Many factors could cause our actual results, level of activity, performance or achievements or future events or developments to differ materially from those expressed or implied by the forward-looking statements, including without limitation, a lack of revenue, insufficient funding, the impact of the COVID-19 pandemic, reliance upon key personnel, the uncertainty of the clinical development process, competition, and other factors set forth in the “Risk Factors” section of the Company’s Annual Information Form, Prospectus Supplement, financial statements and Management Discussion and Analysis which can be found on All clinical development plans are subject to additional funding.

Readers should not place undue reliance on forward-looking statements made in this news release. Furthermore, unless otherwise stated, the forward-looking statements contained in this news release are made as of the date of this news release, and we have no intention and undertake no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by applicable law. The forward-looking statements contained in this news release are expressly qualified by this cautionary statement.