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This is our data centre where we list selected publications in scientific journals. Links to the publications will be included when allowed by copyright law.
In reviewing these publications, it is helpful to note that our lead drug candidate, NVG-291, is the human analog of NVG-291-R, which has been used in most experiments in rodents. NVG-291-R is also most commonly referred to in the literature as intracellular sigma peptide, or ISP.
Please note that this is not a comprehensive list of all publications related to the identified topics. The same article may be present in our list under multiple headings if it relates to multiple subjects. There may be scientific publications relevant to any of the listed topics that have not been identified by NervGen, or that have not been included in this website.
Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke. Luo et al., Cell Reports 2022, Volume 40, Issue 4, 111137.
Regulation of autophagy by inhibitory CSPG interactions with receptor PTPσ and its impact on plasticity and regeneration after spinal cord injury. Experimental Neurology. Tran A.P., Warren P.M., Silver J., 2020; 328:113276.
Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity. Journal of Neurochemistry. Horn K.E., Xu B., Gobert D., et al., 2012; 122(1):147-161.
Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma. Acta Biochimica et Biophysica Sinica. Hou L., Wang J., Zhou Y., Li J., Zang Y., Li J., 2011; 43(12):977-88.
Rapid and robust restoration of breathing long after spinal cord injury. Nature Communications. Warren et al., 2018; 9:4843
Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury. Journal of Neuroinflammation. Dyck S., Kataria H., Alizadeh A., et al., 2018; 15(1):90.
Role of chondroitin sulfate proteoglycan signaling in regulating neuroinflammation following spinal cord injury. Neural Regeneration Research. Dyck S.M., Karimi-Abdolrezaee S., 2018; 13(12):2080-2082.
Targeting proteoglycan receptor PTPσ restores sensory function after spinal cord dorsal root injury by activation of Erks/CREB signaling pathway. Neuropharmacology. Yao M. Sun H., Yuan Q., et al., 2019; 144:208-218.
Automated Gait Analysis Detects Improvements after Intracellular σ Peptide Administration in a Rat Hemisection Model of Spinal Cord Injury. Annals of Biomedical Engineering. Ham T.R., Farrag M., Soltisz A.M., Lakes E.H., Allen K.D., Leipzig N.D., 2019; 47(3):744-753.
Subcutaneous priming of protein-functionalized chitosan scaffolds improves function following spinal cord injury. Materials Science and Engineering: C. Ham T.R., Pukale D.D., Hamrangsekachaee M., Leipzig N.D., 2020; 110:110656.
Chondroitinase Improves Anatomical and Functional Outcomes After Primate Spinal Cord Injury. Nature Neuroscience. Rosenzweig E.S., Salegio E.A., Liang J.J. et al., 2019; 22, 1269–1275
Alzheimer’s disease pathogenesis is dependent on neuronal receptor PTPσ. bioRxiv. Gu Y., Shu Y., Corona A., et al., 2016; 079806.
Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice. Acta Neuropathologica Communications. Howell M.D., Bailey L.A., Cozart M.A., Gannon B.M., Gottschall P.E., 2015; 3:54.
Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology. Experimental Neurology. Yang S., Cacquevel M., Saksida L.M., et al., 2015; 265:48-58.
Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration. Neurobiology of Aging. Yang S., Hilton S., Alves J.N., et al., 2017; 59:197-209.
Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer’s disease. Acta Neuropathologica Communications. Végh M.J., Heldring C.M., Kamphuis W., et al., 2014; 11.
Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation. Neuron. Farhy-Tselnicker I., van Casteren A.C.M., Lee A., Chang V.T., Aricescu A.R., Allen N.J., 2017; 96(2):428-445.e13.
Modulation of Receptor Protein Tyrosine Phosphatase Sigma Increases Chondroitin Sulfate Proteoglycan Degradation through Cathepsin B Secretion to Enhance Axon Outgrowth. Journal of Neuroscience. Tran A.P., Sundar S., Yu M., Lang B.T., Silver J., 2018; 38(23):5399–5414.
Glycan sulfation patterns define autophagy flux at axon tip via PTPRσ-cortactin axis. Nature Chemical Biology. Sakamoto K., Ozaki T., Ko Y-C., et al., 2019; 15(7):699-709.
Receptor protein tyrosine phosphatases control Purkinje neuron firing. Journal Cell Cycle. Brown A.S., Meera P., Quinones G., et al., 2020; 19(2):153-159.
Regulation of autophagy by inhibitory CSPG interactions with receptor PTPσ and its impact on plasticity and regeneration after spinal cord injury. Experimental Neurology. Tran A.P., Warren P.M., Silver J., 2020; 328:113276.
Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias. Nature Communications. Gardner R.T., Wang L., Lang B.T., et al., 2015; 6(1):6235.
Disrupting protein tyrosine phosphatase σ does not prevent sympathetic axonal dieback following myocardial infarction. Experimental Neurology. Johnsen D., Olivas A., Lang B., Silver J., Habecker B., 2016; 276:1–4.
PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation. Scientific Reports. Davis T.B., Yang M., Schell M.J., et al., 2018; 8(1):1-16.
Correlation between the High-Frequency Content of the QRS on Murine Surface Electrocardiogram and the Sympathetic Nerves Density in Left Ventricle after Myocardial Infarction: Experimental Study. Journal of Electrocardiology. Sedaghat G., Gardner R.T., Kabir M.M., Ghafoori E., Habecker B.A., Tereshchenko L.G., 2017; 50(3):323-331.
ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury. Neural regeneration research. Lv, Shi-Qin, and Wutian Wu. Vol. 16,8 (2021): 1598-1605. doi:10.4103/1673-5374.294565
Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury. Journal of Neuroscience. Massey, J. M. et al., 2006; 26, 4406–4414.
Alterations in chondroitin sulfate proteoglycan expression occur both at and far from the site of spinal contusion injury. Experimental Neurology. Andrews, E.M., Richards, R.J., Yin, F.Q., Viapiano, M.S., Jakeman, L.B., 2012; 235, 174–187.
Quantitative changes in perineuronal nets in development and posttraumatic condition. Journal of Molecular Histology. Lipachev, N. et al., 2019; 50, 203–216.
Reactivation of ocular dominance plasticity in the adult visual cortex. Science. Pizzorusso, T. et al., 2002; 298, 1248–1251.
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NervGen (TSX-V: NGEN, OTCQX: NGENF) is a clinical stage biotech company dedicated to developing innovative treatments that enable the nervous system to repair itself following damage, whether due to injury or disease. NervGen’s lead drug candidate, NVG-291, is being evaluated in a Phase 1b/2a clinical trial. The company’s lead target indication is spinal cord injury.
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